BeOne ZIIHERA trial shows survival improvement

• BeOne Medicines reported Phase 3 HERIZON-GEA-01 data showing ZIIHERA plus chemotherapy improved overall survival compared with trastuzumab plus chemotherapy.
• The trial evaluated 914 patients with HER2-positive locally advanced or metastatic gastroesophageal adenocarcinoma.
• BeOne said the results support continued development of ZIIHERA and TEVIMBRA-based treatment combinations in first-line cancer care.

BeOne Medicines (NASDAQ:ONC) reported Phase 3 HERIZON-GEA-01 trial results showing ZIIHERA (zanidatamab) plus chemotherapy produced a statistically significant improvement in overall survival compared with trastuzumab plus chemotherapy in first-line treatment of HER2-positive gastroesophageal adenocarcinoma.

The second interim analysis follows earlier results from the trial, which showed progression-free survival and overall survival benefits for the TEVIMBRA plus ZIIHERA and chemotherapy combination.

The HERIZON-GEA-01 trial randomized 914 patients across more than 30 countries, comparing ZIIHERA plus chemotherapy, ZIIHERA with TEVIMBRA and chemotherapy, and trastuzumab plus chemotherapy, with overall survival and progression-free survival as primary endpoints.

BeOne Medicines said the safety profile at the second interim analysis remained generally consistent with previous findings.

BeOne Medicines develops oncology medicines, including ZIIHERA and TEVIMBRA, which are being studied across multiple solid tumor types and treatment settings.

ZIIHERA is a HER2-targeting antibody developed through partnerships involving BeOne Medicines, Jazz Pharmaceuticals, and Zymeworks, while TEVIMBRA is a PD-1 antibody used across multiple cancer indications.