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IDEAYA Biosciences (NASDAQ:IDYA) and Servier reported breakthrough topline results today from the Phase 2/3 OptimUM-02 trial, demonstrating that the combination of darovasertib and crizotinib significantly improved outcomes for patients with first-line HLA-A*02:01-negative metastatic uveal melanoma (MUM).

Goldman Sachs Group's equity traders beat their own previous all-time high by more than $1 billion, reporting revenue of $5.33 billion for the first three months of the year. Dani Burger reports on Bloomberg Television.

While the dollar's demise has been greatly exaggerated on many occasions, the war with Iran has put potentially irreversible strain on the global trading system, with gold reserves having eclipsed central bank holdings of valuation-adjusted dollar assets for the first time in the Bretton Woods II era. As President Trump rips up Pax Americana, owning fewer dollar assets becomes increasingly logical, and it's hard not to see the dollar's dominance continuing to ebb away over time, with gold's fortunes further revived.

The leader of South Africa's second-biggest party warned the country faces "profound risk" as factions within the ruling ANC battle over its next president. Newly elected Democratic Alliance leader, Geordin Hill-Lewis, spoke to Bloomberg's Joumanna Bercetche from Johannesburg.

Anna Edwards, Guy Johnson, Tom Mackenzie and Adam Linton break down today's key themes for analysts and investors on "Bloomberg: The Opening Trade."

Michael Metcalfe, global head of macro strategy at State Street Global Markets, discusses the ongoing impact of the Iran war on markets, inflation and the global economy. He speaks on Bloomberg Television.

Lebanese Minister of Industry Joe Issa el-Khoury says the ongoing conflict in the south of the country was "imposed" and triggered by Hezbollah. In an exclusive TV interview with Bloomberg's Joumanna Bercetche, he argued that Lebanon must assert its own decision-making rather than be drawn into broader regional dynamics.

Economist and CEO Nouriel Roubini says the planned US naval blockade in the Strait of Hormuz is merely a "game of chicken" which Iran can outlast, and could allow Tehran to recover, keep oil prices higher and push global growth weaker. He speaks to Bloomberg's David Ingles at the Greenwich Economic Forum in Hong Kong.

K2 Asset Management's George Boubouras, Managing Director and Head of Research, Investments and Advisory, says that while the Iran conflict and naval blockade are driving sharp volatility, long term investors should look through the headlines rather than trade on every twist. He expects continued price and volume shocks to lift inflation and raise recession risks. but sees resilient underlying earnings in developed markets like the US.

ONYX Capital Group MD Jorge Montepeque says US President Donald Trump's threat to blockade the Strait of Hormuz 'makes no sense'. He speaks with Haslinda Amin on "Insight with Haslinda Amin."

The US and Iran failed to reach a deal in marathon talks in Pakistan, jeopardizing a ceasefire reached last week that raised hopes of a quick resolution to the war. Bloomberg's Joumanna Bercetche has the latest.

Michael Ratney, Former US Ambassador to Saudi Arabia and US Special Envoy for Syria, says the Trump Administration's plan to move US Navy forces to block the Strait of Hormuz 'injects enormous element of risk and uncertainty' that could lead to more spikes in energy prices and potential retaliation from Iran. He speaks with Shery Ahn and Haidi Stroud Watts on "Bloomberg: The Asia Trade".