Watertown, Massachusetts-based Acrivon Therapeutics (NASDAQ:ACRV) provided an interim clinical update across its precision oncology pipeline, highlighted by promising response rates for its lead candidate ACR-368 in an ongoing Phase 2b trial.
In the ACR-368 study utilizing the company's proprietary EDC (estimated dose concentration) approach, interim data showed an overall objective response rate of 39%, rising to 44% in patients with two or fewer prior lines of therapy.
Notably, the confirmed objective response rate reached 67% in biomarker-positive serous endometrial cancer patients (N=12) and 52% across all serous subjects (N=23).
The company plans to expand Arm 3, evaluating ACR-368 in combination with ultra-low dose gemcitabine, to enroll up to 90 serous cancer patients without requiring biopsy.
Enrollment completion is targeted for the fourth quarter of 2026, with European sites expected to initiate in the first quarter of 2026.
Acrivon has submitted a Phase 3 protocol for ACR-368 combined with anti-PD-1 therapy and anticipates global trial readiness by mid-2026.