Seres Therapeutics annual profit jumps on asset sale, but faces cash crunch

Seres Therapeutics (NASDAQ:MCRB) delivered a rare profitable year in 2025, though the black ink was the result of a major divestiture rather than a surge in drug sales.

The Cambridge, Massachusetts-based microbiome specialist reported a full-year profit of $5.7 million, or $0.64 per share, reversing a massive $125.8 million loss from the prior year.

The turnaround was fueled by an $80.7 million gain from the sale of its VOWST business—the first FDA-approved oral microbiome therapeutic—to Nestlé Health Science.

Despite the annual profit, the company’s fourth-quarter results highlighted the persistent burn rate of its remaining clinical programs.

For the three months ended Dec. 31, Seres posted a net loss of $15.3 million, or $1.76 per share, on revenue of just $438,000.

Under the leadership of newly appointed interim CEO Richard Kender, Seres is undergoing a radical "reboot."

The company is pausing internal investment in its most advanced candidate, SER-155, while it hunts for a partner to fund Phase 2 trials.

Instead, resources are being diverted toward earlier-stage immunological research, supported by a 30% workforce reduction aimed at preserving capital.

The stakes for the pivot are high.

Seres ended 2025 with $45.8 million in cash and equivalents.

Management warned on Thursday that this liquidity—even with the cost-cutting measures—is only expected to fund operations through the third quarter of 2026.