Bio-Techne and Refeyn unveil integrated workflow for enhanced biologic analysis

Bio-Techne (NASDAQ:TECH) and Refeyn have launched a new integrated analytical workflow designed to streamline the characterization of complex biologics.

The collaboration links Bio-Techne’s MauriceFlex™ imaged capillary isoelectric focusing (icIEF) fractionation technology with Refeyn’s TwoMP mass photometry system, providing a robust solution for the analysis of bispecific antibodies and biosimilars.

The primary objective of this integration is to reduce development timelines and lower risks associated with the production of sophisticated therapeutic proteins.

By combining these two distinct technologies, researchers can now perform a four-hour process that directly correlates charge variants with size and aggregation profiles.

Crucially, this workflow operates at the nanogram level, allowing for high-sensitivity analysis with minimal sample volume.

The ability to link icIEF fractionation—which separates protein charge variants—with the precise mass measurement and aggregation data provided by mass photometry represents a significant advancement for developers.

Historically, these analyses often required separate, time-consuming workflows.

The unified approach aims to provide a clearer understanding of protein quality earlier in the development lifecycle, which is essential for meeting regulatory standards and optimizing manufacturing efficiency.