Passage Bio (NASDAQ:PASG) reported its full-year 2025 financial results on Tuesday, detailing a leaner operational structure and significant enrollment momentum for its lead gene therapy candidate in frontotemporal dementia.
The Philadelphia-based genetic medicines company posted a net loss of $45.5 million for 2025, or $14.35 per share, a notable improvement from the $64.8 million loss recorded in 2024.
The narrowing deficit reflects a strategic 42% reduction in research and development spending following the out-licensing of non-core programs and a focus on high-priority clinical assets.
As of December 31, 2025, the company held $46.3 million in cash and equivalents, which management expects will fund operations through the first quarter of 2027.
The financial update was paired with critical operational updates for the upliFT-D Phase 1/2 study, which is evaluating PBFT02 in patients with frontotemporal dementia (FTD) caused by GRN or C9orf72 mutations.
The company has successfully enrolled the first three patients in Cohort 3 and dosed the first patient in Cohort 4, marking the first administration of PBFT02 to the FTD-C9orf72 population at Dose 2.