Venezuelan President Nicolás Maduro said he is open to dialogue with the United States on drug trafficking and oil.
In an interview with state television, Maduro said talks could take place “wherever they want and whenever they want.”
His comments follow weeks of escalating pressure from Washington against his government.
The remarks come as US forces have intensified operations against suspected drug-smuggling vessels in the Caribbean and eastern Pacific.
US authorities said more than 30 strikes have been carried out on boats since early September.
Those operations have resulted in more than 110 deaths, according to official US figures.
The latest incident occurred on Wednesday, when two boats were struck, killing five people on board.
US President Donald Trump earlier claimed a strike had hit a Venezuelan docking facility linked to drug trafficking.
Media reports said the alleged strike was conducted by the CIA using a drone.
This could be something we talk about in a few days.
Maduro said, when asked to confirm the incident.
Maduro also said Venezuela is willing to discuss oil exports and migration with Washington.
The US has accused Venezuela of facilitating mass migration, a claim Maduro has rejected.
Washington has also seized oil tankers linked to Venezuela, citing sanctions enforcement.
Venezuela described the tanker seizures as acts of international piracy.